Isco, Kroos, and Modric were very good players who could control the center of the pitch while also spraying defense-splitting and accurate passes forward, however, they weren't especially defensively talented.
They had been able to control the pace of the game and the center of the midfield because they were good at moving the ball around and playing possessively, however, now that the ball had to get to the front very quickly, they couldn't spend too much holding the ball before sending it forward for the attackers to have a go at scoring a goal.
Unfortunately, the forwards couldn't hold on to the ball as that was the most hectic place on the pitch for the Madrid team, hence they were losing the ball more often.
With Uventus having new energy on the flanks in the person of Jason and Dybala, things turned bad for the Madrid side very quickly.
{Once again, Rodrygo is stopped by Chiellini and Uventus have the ball}
